Biography
In her research, Feng studies transplantation tolerance, a transplant recipient's ability to maintain normal organ function with minimal or no use of immunosuppressive drugs. With funding from the National Institutes of Health, she has led several multicenter clinical trials to study tolerance in both adult and pediatric liver transplant recipients.
Feng is a graduate of Harvard College, where she received the prestigious Marshall Scholarship. She completed a doctorate in molecular biology at the University of Cambridge and earned her medical degree at Stanford University School of Medicine. She completed a general surgery residency at Brigham and Women's Hospital, followed by a transplant fellowship at UCSF.
Feng has held leadership positions in prominent professional societies and with the United Network for Organ Sharing. She has organized several national conferences addressing issues critical to the transplantation community, serves on the editorial board of the New England Journal of Medicine and is the editor-in-chief for the American Journal of Transplantation.
Dr. Feng was elected to be a member of the National Academy of Medicine in 2023.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 12/2020 | |
Stanford University | M.D. | School of Medicine | 1990 |
Board Certifications
American Board of Surgery, 1996
Collaboration Interests
I am interested in:
- physician scientist
Clinical Expertise
Expanded Criteria Donor Kidney Transplantation
Immunosuppression for Liver Transplantation
Kidney Transplantation
Liver Transplantation
MELD Allocation and Living Donor Liver Transplantation
Pancreas Transplantation
Clinical Trials
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Disease, Liver Transplant| Start Date: | End Date:
- Liver Transplantation With Tregs at UCSF (NCT03654040)Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
- Related Conditions: Liver Transplant| Start Date: | End Date:
Program Affiliations
- Clinical Fellowship, Division of Transplantation
- The Liver Center at UCSF
- Director, Expanded Criteria Donor Kidney Transplant Program, University of California, San Francisco
- UCSF Hellen Diller Family Comprehensive Cancer Center
Grants and Funding
- PROSPECTIVE LONGITUDINAL STUDY OF IWITH SCREEN FAILURES SECONDARY TO HISTOPATHOLOGY | NIH | 2017-08-10 - 2021-07-31 | Role: Principal Investigator
- Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation | NIH | 2014-06-01 - 2021-05-31 | Role: Principal Investigator
- Polyclonal Tregs to Promote Tolerance in Pediatric Liver Transplant Recipients | NIH | 2013-02-01 - 2020-01-31 | Role: Principal Investigator
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients | NIH | 2012-07-27 - 2019-06-30 | Role: Principal Investigator
- Donor-Specific Regulatory T Cell Therapy in Liver Transplantation | NIH | 2012-04-01 - 2014-03-31 | Role: Principal Investigator
- Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients | NIH | 2009-09-30 - 2013-03-31 | Role: Principal Investigator
Research Narrative
Dr. Feng's research interest focuses on transplant immunology, with a particular focus on determinants of organ tolerance. She is also investigating novel immunosuppressive regimens and pursuing immunosuppression withdrawal in selected liver transplant recipients. By studying the immune profiles of transplant patients who are successfully weaned from immunosuppressants, she and her group hope to predict prospectively which patients may be good candidates for immunosuppression withdrawal.
Research Interests
- Immunosuppression Withdrawal for Stable Pediatric Living Donor Liver Transplant Recipients
- Immunosuppression Withdrawal and Identification of a Profile Predictive of Tolerance
- Defining the Optimal Immunosuppression for Specific Transplant Settings
- Expanded Criteria Donors
- Novel Immunosuppression Strategies for Liver Transplantation
- Strategies to Decrease Ischemia Reperfusion Injury to Improve Early Graft Function after Kidney Transplantation
- Improving Long-term Outcomes for Liver Transplant Recipients
Publications
- Donor-specific Immune Senescence as a Candidate Biomarker of Operational Tolerance Following Liver Transplantation in Adults: Results of a Prospective, Multicenter Cohort Study.| | PubMed
- Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.| | PubMed
- The type, duration, and severity of pretransplant kidney injury predict prolonged kidney dysfunction after liver transplantation.| | PubMed
- The future of liver transplantation.| | PubMed
- Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health.| | PubMed
- The Banff process-Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation.| | PubMed
- A modified Hospital Frailty Risk Score for patients with cirrhosis undergoing abdominal operations.| | PubMed
- Advancing mouse models for transplantation research.| | PubMed
- Transforming the Future of Surgeon-Scientists.| | PubMed
- Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis.| | PubMed
- Kidney transplantation in a patient with anomalous iliofemoral vasculature.| | PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed
- Mapping children by ALT 4-5 years after liver transplant: Potential individual and population applications.| | PubMed
- Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.| | PubMed
- Real-world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact.| | PubMed
- Liver transplantation immunology: Immunosuppression, rejection, and immunomodulation.| | PubMed
- Supporting Robust Teamwork - Bridging Technology and Organizational Science.| | PubMed
- Immunosuppression after pediatric liver transplant: The parents' perspective.| | PubMed
- Addressing sex-based disparities in solid organ transplantation in the United States - a conference report.| | PubMed
- Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.| | PubMed
- Next-generation pathology detection of T cell-antigen-presenting cell immune synapses in human liver allografts.| | PubMed
- Standardizing the histological assessment of late posttransplantation biopsies from pediatric liver allograft recipients.| | PubMed
- Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management.| | PubMed
- Graft Fibrosis Over 10 to 15 Years in Pediatric Liver Transplant Recipients: Multicenter Study of Paired, Longitudinal Surveillance Biopsies.| | PubMed
- We Asked the Experts: Toward Personalized Immunosuppression for Liver Transplant Recipients.| | PubMed
- Not everything that counts can be counted: Tracking long-term outcomes in pediatric liver transplant recipients.| | PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed
- Impact of Donor and Recipient Clinical Characteristics and Hepatic Histology on Steatosis/Fibrosis Following Liver Transplantation.| | PubMed
- Frailty, mortality, and health care utilization after liver transplantation: From the Multicenter Functional Assessment in Liver Transplantation (FrAILT) Study.| | PubMed
- The molecular phenotypes of injury, steatohepatitis, and fibrosis in liver transplant biopsies in the INTERLIVER study.| | PubMed
- Baby Steps: Understanding Allograft Fibrosis in Pediatric Liver Transplantation.| | PubMed
- Non-invasive alloimmune risk stratification of long-term liver transplant recipients.| | PubMed
- Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management.| | PubMed
- Improvements in Disease-Specific Health-Related Quality of Life of Pediatric Liver Transplant Recipients During Immunosuppression Withdrawal.| | PubMed
- Transplantation From Older Donors: Can Senolytics Turn Back the Clock?| | PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | PubMed
- Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.| | PubMed
- Rapid Modification of Workflows and Fellow Staffing at a Single Transplant Center to Address the COVID-19 Crisis.| | PubMed
- Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.| | PubMed
- The molecular diagnosis of rejection in liver transplant biopsies: First results of the INTERLIVER study.| | PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | PubMed
- IgG4 donor-specific HLA antibody profile is associated with subclinical rejection in stable pediatric liver recipients.| | PubMed
- Prevalence and Impact of De Novo Donor-Specific Antibodies During a Multicenter Immunosuppression Withdrawal Trial in Adult Liver Transplant Recipients.| | PubMed
- Posttransplant biopsy risk for stable long-term pediatric liver transplant recipients: 451 percutaneous biopsies from two multicenter immunosuppression withdrawal trials.| | PubMed
- Outcomes of immunosuppression minimization and withdrawal early after liver transplantation.| | PubMed
- Reply.| | PubMed
- Liver transplants for noncitizens/nonresidents: What is the problem, and what should be done?| | PubMed
- Evidence of Chronic Allograft Injury in Liver Biopsies From Long-term Pediatric Recipients of Liver Transplants.| | PubMed
- Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.| | PubMed
- Reply.| | PubMed
- Physical frailty after liver transplantation.| | PubMed
- The Liver Frailty Index Improves Mortality Prediction of the Subjective Clinician Assessment in Patients With Cirrhosis.| | PubMed
- Tolerance after liver transplantation: Where are we?| | PubMed
- Tolerance in clinical liver transplantation.| | PubMed
- Living donor liver transplantation in high Model for End-Stage Liver Disease score patients.| | PubMed
- Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference.| | PubMed
- Development of a novel frailty index to predict mortality in patients with end-stage liver disease.| | PubMed
- Optimizing Graft Survival by Pretreatment of the Donor.| | PubMed
- Current status of tolerance in kidney transplantation.| | PubMed
- The questions not the answers: Outcomes after pediatric liver transplantation.| | PubMed
- A Comparison of Muscle Function, Mass, and Quality in Liver Transplant Candidates: Results From the Functional Assessment in Liver Transplantation Study.| | PubMed
- Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R.| | PubMed
- Response to clinical assessments of health status as a potential marker to identify patients who are too sick to undergo transplantation.| | PubMed
- Spontaneous and induced tolerance for liver transplant recipients.| | PubMed
- Functional decline in patients with cirrhosis awaiting liver transplantation: Results from the functional assessment in liver transplantation (FrAILT) study.| | PubMed
- Functional impairment in older liver transplantation candidates: From the functional assessment in liver transplantation study.| | PubMed
- Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients.| | PubMed
- The corrected donor age for hepatitis C virus-infected liver transplant recipients.| | PubMed
- Clinician assessments of health status predict mortality in patients with end-stage liver disease awaiting liver transplantation.| | PubMed
- Renal outcomes of simultaneous liver-kidney transplantation compared to liver transplant alone for candidates with renal dysfunction.| | PubMed
- Combined effects of recipient age and model for end-stage liver disease score on liver transplantation outcomes.| | PubMed
- Expanded criteria donors.| | PubMed
- Multiple listings as a reflection of geographic disparity in liver transplantation.| | PubMed
- Evaluation for liver transplantation in adults: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation.| | PubMed
- Donor Risk Index for African American liver transplant recipients with hepatitis C virus.| | PubMed
- Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.| | PubMed
- Offer patterns of nationally placed livers by donation service area.| | PubMed
- An examination of liver offers to candidates on the liver transplant wait-list.| | PubMed
- Increasing disparity in waitlist mortality rates with increased model for end-stage liver disease scores for candidates with hepatocellular carcinoma versus candidates without hepatocellular carcinoma.| | PubMed
- Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants.| | PubMed
- KIR genotypic diversity can track ancestries in heterogeneous populations: a potential confounder for disease association studies.| | PubMed
- Kidney transplant performed after liver transplant: a single center experience.| | PubMed
- Preface: Optimization of outcomes for children after solid organ transplantation.| | PubMed
- Tolerance: is it achievable in pediatric solid organ transplantation?| | PubMed
- Management of the liver transplant patient.| | PubMed
- Factors influencing liver transplant length of stay at two large-volume transplant centers.| | PubMed
- Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation.| | PubMed
- Increased donor risk: who should bear the burden?| | PubMed
- Long-term histological effects of preemptive antiviral therapy in liver transplant recipients with hepatitis C virus infection.| | PubMed
- Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both?| | PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed
- Steatotic livers for liver transplantation--life-saving but at a cost.| | PubMed
- Allocation policy for hepatocellular carcinoma in the MELD era: room for improvement?| | PubMed
- Linking the US transplant registry to administrative claims data: expanding the potential of transplant research.| | PubMed
- Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy.| | PubMed
- In a MELD-based economy, how can we fight off inflation?| | PubMed
- Optimizing living donor kidney graft function by donor-recipient pair selection.| | PubMed
- Magnetic resonance imaging of hepatocellular carcinoma mimicking focal nodular hyperplasia: a potential pitfall in patients with cirrhosis?| | PubMed
- How can we define expanded criteria for liver donors?| | PubMed
- Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation.| | PubMed
- Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice.| | PubMed
- Trends over a decade of pediatric liver transplantation in the United States.| | PubMed
- A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation.| | PubMed
- End stage polycystic kidney disease: indications and timing of native nephrectomy relative to kidney transplantation.| | PubMed
- Expanded criteria donor kidney allocation: marked decrease in cold ischemia and delayed graft function at a single center.| | PubMed
- Selecting livers for transplantation: can beggars be choosers?| | PubMed
- PELD: working well, but only half of the time?| | PubMed
- Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient.| | PubMed
- Impact of sirolimus on early graft function after deceased-donor kidney transplantation.| | PubMed
- An older liver in the hand, or a (possibly) younger liver in the bush?| | PubMed
- Surgical challenges in transplantation: the Fourth Annual American Society of Transplant Surgeons' State-of-the-Art Winter Symposium.| | PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | PubMed
- Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.| | PubMed
- Increased rejection in living unrelated versus living related kidney transplants does not affect short-term function and survival.| | PubMed
- Developmental context determines latency of MYC-induced tumorigenesis.| | PubMed
- Comparison of outcomes after delayed graft function: sirolimus-based versus other calcineurin-inhibitor sparing induction immunosuppression regimens.| | PubMed
- Hepatitis C etiology of liver disease is strongly associated with early acute rejection following liver transplantation.| | PubMed
- National conference to assess antibody-mediated rejection in solid organ transplantation.| | PubMed
- Early graft function after living donor kidney transplantation predicts rejection but not outcomes.| | PubMed
- An uncomfortable silence em leader while we all search for a better reporter gene in adult stem cell biology.| | PubMed
- Organ donors with malignant gliomas: an update.| | PubMed
- Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury.| | PubMed
- Tumors and transplantation: The 2003 Third Annual ASTS State-of-the-Art Winter Symposium.| | PubMed
- Death from donor-transmitted malignancy despite emergency liver retransplantation.| | PubMed
- Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation.| | PubMed
- Management of lymphoceles after renal transplantation: laparoscopic versus open drainage.| | PubMed
- Sirolimus prolongs recovery from delayed graft function after cadaveric renal transplantation.| | PubMed
- Expanded criteria donors for kidney transplantation.| | PubMed
- Organ donors with positive viral serology or malignancy: risk of disease transmission by transplantation.| | PubMed
- Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor.| | PubMed
- Targeted gene therapy with CD40Ig to induce long-term acceptance of liver allografts.| | PubMed
- HIV-1 tat trans-activation requires the loop sequence within tar.| | PubMed