University of California San Francisco

Joseph Cuschieri-lg-headshot
Joseph
Cuschieri
MD, FACS

Professor of Surgery
Division of General Surgery
Trauma and Surgical Critical Care
Chief of Surgery, Zuckerberg San Francisco General Hospital

UCSF Diversity, Equity, and Inclusion Champion badge

Address

1001 Potrero Avenue, #3A25
San Francisco, CA 94110
United States

Email: [email protected]

ORCID: 0000-0003-1456-6841

Biography

Joseph Cuschieri M.D. earned his Bachelor of Science Degree in Biochemistry from the University of Michigan, and his Medical Degree from Wayne State University School of Medicine.  He completed his general surgery residence and surgical critical care fellowship at Henry Ford Hospital in Detroit, Michigan.  Upon completion of his clinical training, he completed a 2-year NIH T32 Fellowship in the field of Trauma/Burn/Inflammation.

Dr. Cuschieri is certified by the American Board of Surgery in General Surgery with subspecialty certification in Surgical Critical Care.

Upon completion of his fellowship in 2002, Dr. Cuschieri joined the faculty at the University of Cincinnati School of Medicine.  After a couple of years he left Cincinnati and returned to Seattle, joining the faculty at the University of Washington School of Medicine where he served as the Medical Director of Surgical Critical Care, Interim Associate Medical Director of Critical Care, Associate Medical Director of Surgical Services, and Program Director of Surgical Critical Care.  Dr. Cuschieri left Washington and came to UCSF in 2021 to join the faculty in the Department of Surgery as Professor and Trauma Medical Director at the Zuckerberg San Francisco General Hospital and Trauma Center.

Dr. Cuschieri currently serves as Principal Investigator, Co-Principle investigator, or Co-Investigator on 3 federally funded grants and has authored or co-authored over 170 peer-reviewed articles and more than 10 book chapters.  His national service includes active participation in major trauma, critical care, and surgical societies including the American Association for the Surgery of Trauma and the Society of Surgical Critical Care Program Directors.  He also serves on the Editorial Board for the Journal of Trauma and Acute Care Surgery.

Awards & Honors

Award Conferred By Date
John K. Stevenson Faculty Teaching Award in Surgery University of Washington School of Medicine 2019
CDC HA-VTE Prevention Challenge Champion Centers of Disease Control 2015
Castle Connelly Top Doctors Castle Connelly Inc. 2006/2021
Joseph Sussman Memorial Award Surgical Infection Society 2006

Education

Institution Degree Dept or School End Date
University of California Diversity, Equity, and Inclusion Champion Training 09/2021
University of Washington T32 Trauma/Burn/Inflammation 6/2002
Henry Ford Hospital Medical Center General Surgery 6/2000
Henry Ford Hospital Medical Center Surgical Critical Care 6/1998
Wayne State University School of Medicine MD Medicine 6/1994
University of Michigan BS Biochemistry 6/1990

Clinical Trials

  1. Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury (NCT06654193)
    Related Conditions: Acute Kidney Injury| Start Date: | End Date:

Grants and Funding

  • Surgery Research Training Program | NIH | 2017-07-01 - 2022-06-30 | Role: Co-Investigator
  • Validation of a Genomics Based Prognostic in Severe Trauma | NIH | 2013-06-01 - 2017-04-30 | Role: Co-Investigator
  • A Randomzied Phase II Trial of CMV Prevention in Acute Lung Injury | NIH | 2010-06-01 - 2016-12-31 | Role: Co-Investigator
  • POSTDOCTORAL TRAINING | NIH | 1975-07-01 - 2015-06-30 | Role: Co-Investigator
  • Bedside Genomics in Severe Trauma | NIH | 2012-09-25 - 2014-08-31 | Role: Co-Investigator
  • Planning a Multi-Center Trial of Interferon-gamma in Trauma Patients | NIH | 2012-09-01 - 2014-08-31 | Role: Co-Investigator
  • SIS multicenter study of duration of antibiotics for intraabdominal infection | NIH | 2007-09-11 - 2014-08-31 | Role: Co-Investigator
  • Inflammation and the Host Responses to Injury | NIH | 2000-09-01 - 2013-08-31 | Role: Co-Investigator
  • TRAUMA &SEPSIS INDUCED CHANGES IN IMMUNE CELL MEMBRANE RECEPTOR TRAFFICKING | NIH | 2007-09-01 - 2013-06-30 | Role: Principal Investigator
  • Hypertonic Modulation of Inflammation following Injury | NIH | 2007-06-11 - 2012-11-30 | Role: Co-Investigator

Research Narrative

Dr. Cuschieri is a clinical and translational researcher who has worked to decipher the effects of initial injury on subsequent alterations immune function, and development of evidence based practices to improve care of injured and septic patients.  His main research focus is in the fields of polytrauma, hemorrhagic shock and neurotrauma with a specific interest in long-term outcomes following injury. From a critical care perspective, his main focus has been on organ support in the critically ill and septic patient.

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 201
  1. The Epidemiology of Genitourinary Self-Inflicted Injuries: Analysis of the National Trauma Databank.
    Hakam N, Ghaffar U, Abbasi B, Li KD, Fernandez A, Patel HV, Cuschieri J, Breyer BN| | PubMed
  2. Multiple organ failure: What you need to know.
    Brakenridge S, Kornblith L, Cuschieri J| | PubMed
  3. Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma.
    Barry M, Trivedi A, Miyazawa B, Vivona LR, Shimmin D, Pathipati P, Keane C, Cuschieri J, Pati S| | PubMed
  4. Antibiotic prophylaxis in injury: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.
    Appelbaum RD, Farrell MS, Gelbard RB, Hoth JJ, Jawa RS, Kirsch JM, Mandell S, Nohra EA, Rinderknecht T, Rowell S, Cuschieri J, Stein DM| | PubMed
  5. Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.
    Nohra E, Appelbaum RD, Farrell MS, Carver T, Jung HS, Kirsch JM, Kodadek LM, Mandell S, Nassar AK, Pathak A, Paul J, Robinson B, Cuschieri J, Stein DM| | PubMed
  6. Surgical and procedural antibiotic prophylaxis in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.
    Farrell MS, Agapian JV, Appelbaum RD, Filiberto DM, Gelbard R, Hoth J, Jawa R, Kirsch J, Kutcher ME, Nohra E, Pathak A, Paul J, Robinson B, Cuschieri J, Stein DM| | PubMed
  7. Scanning the aged to minimize missed injury: An EAST multicenter study.
    Ho VP, Kishawi SK, Hill H, O'Brien J, Ratnasekera A, Seng SS, Ton TH, Butts CA, Muller A, Diaz BF, Baltazar GA, Petrone P, Pacheco TBS, Morrissey S, Chung T, Biller J, Jacobson LE, Williams JM, Nebughr CS, Udekwu PO, Tann K, Piehl C, Veatch JM, Capasso TJ, Kuncir EJ, Kodadek LM, Miller SM, Altan D, Mentzer C, Damiano N, Burke R, Earley A, Doris S, Villa E, Wilkinson MC, Dixon JK, Wu E, Moncrief ML, Palmer B, Herzing K, Egodage T, Williams J, Haan J, Lightwine K, Colling KP, Harry ML, Nahmias J, Tay-Lasso E, Cuschieri J, Hinojosa CJ, Claridge JA| | PubMed
  8. Balanced resuscitation: the role during non-massive hemorrhage.
    Garber K, Kornblith L, Cuschieri J| | PubMed
  9. Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.
    Sperry JL, Guyette FX, Rosario-Rivera BL, Kutcher ME, Kornblith LZ, Cotton BA, Wilson CT, Inaba K, Zadorozny EV, Vincent LE, Harner AM, Love ET, Doherty JE, Cuschieri J, Kornblith AE, Fox EE, Bai Y, Hoffman MK, Seger CP, Hudgins J, Mallett-Smith S, Neal MD, Leeper CM, Spinella PC, Yazer MH, Wisniewski SR, Cold Stored Platelet for Hemorrhagic Shock (CRISP-HS) Study Group| | PubMed
  10. Regulation of Vascular Endothelial Integrity by Mesenchymal Stem Cell Extracellular Vesicles after Hemorrhagic Shock and Trauma.
    Barry M, Trivedi A, Miyazawa B, Vivona L, Shimmin D, Pathipati P, Keane C, Cuschieri J, Pati S| | PubMed
  11. Insights from CTTACC: immune system reset by cellular therapies for chronic illness after trauma, infection, and burn.
    Bertram K, Cox C, Alam H, Lowell C, Cuschieri J, Parekkadan B, Pati S| | PubMed
  12. Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Secondary Analysis of a Randomized Clinical Trial.
    O'Hara NN, Frey KP, Stein DM, Levy JF, Slobogean GP, Castillo R, Firoozabadi R, Karunakar MA, Gary JL, Obremskey WT, Seymour RB, Cuschieri J, Mullins CD, O'Toole RV,
    METRC    | | PubMed
  13. Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopedic trauma patients: A secondary analysis of the PREVENT CLOT trial.
    O'Hara NN, O'Toole RV, Frey KP, Castillo RC, Cuschieri J, Haut ER, Slobogean GP, Firoozabadi R, Christmas AB, Obremskey WT, Carlini AR, Gaski GE, Kutcher ME, Marvel D, Stein DM, Major Extremity Trauma Research Consortium (METRC)| | PubMed
  14. Screening for Intimate Partner Violence in Trauma: Results of a Quality Improvement Project.
    Decker H, Schwab M, Shao S, Kaki D, Melhado C, Cuschieri J, Bongiovanni T| | PubMed
  15. The injured monocyte: The link to chronic critical illness and mortality following injury.
    Cuschieri J, Kornblith L, Pati S, Piliponsky A| | PubMed
  16. Trial Participation and Outcomes Among English-Speaking and Spanish-Speaking Patients With Appendicitis Randomized to Antibiotics: A Secondary Analysis of the CODA Randomized Clinical Trial.
    Serrano E, Voldal EC, Machado-Aranda D, DeUgarte DA, Kao L, Drake T, Winchell R, Cuschieri J, Krishnadasan A, Talan DA, Siparsky N, Ayoung-Chee P, Self WH, McGonagill P, Mandell KA, Liang MK, Dodwad SJ, Thompson CM, Padilla RM, Fleischman R, Price TP, Jones A, Bernardi K, Garcia L, Evans HL, Sanchez SE, Odom S, Comstock BA, Heagerty PJ, Lawrence SO, Monsell SE, Fannon EEC, Kessler LG, Flum DR, Davidson GH, Writing Group for the CODA Collaborative| | PubMed
  17. Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.
    Seshadri A, Cuschieri J, Kaups KL, Knowlton LM, Kutcher ME, Pathak A, Rappold J, Rinderknecht T, Stein DM, Young J, Michetti CP| | PubMed
  18. Developing a National Trauma Research Action Plan: Results from the long-term outcomes research gap Delphi survey.
    Herrera-Escobar JP, Reidy E, Phuong J, Brasel KJ, Cuschieri J, Fallat M, Potter BK, Price MA, Bulger EM, Haider AH, Bonne S, Brasel KJ, Cuschieri J, de Roon-Cassini T, Dicker RA, Fallat M, Ficke JR, Gabbe B, Gibran NS, Heinemann AW, Ho V, Kao LS, Kellam JF, Kurowski BG, Levy-Carrick NC, Livingston D, Mandell SP, Manley GT, Michetti CP, Miller AN, Newcomb A, Okonkwo D, Potter BK, Seamon M, Stein D, Wagner AK, Whyte J, Yonclas P, Zatzick D, Zielinski MD, NTRAP Long-term Outcomes Panel| | PubMed
  19. Alcohol Intoxication Is Associated With Bladder Injury and Bladder Surgical Repair in Patients Sustaining Motor Vehicle Collisions.
    Lui JL, Hakam N, Shaw NM, Cuschieri J, Abbasi B, Breyer BN| | PubMed
  20. Management of Decompensated Cirrhosis in the Surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document.
    Seshadri A, Appelbaum R, Carmichael SP, Cuschieri J, Hoth J, Kaups KL, Kodadek L, Kutcher ME, Pathak A, Rappold J, Rudnick SR, Michetti CP| | PubMed
  21. Perception of Treatment Success and Impact on Function with Antibiotics or Appendectomy for Appendicitis: A Randomized Clinical Trial with an Observational Cohort.
    Thompson CM, Voldal EC, Davidson GH, Sanchez SE, Ayoung-Chee P, Victory J, Guiden M, Bizzell B, Glaser J, Hults C, Price TP, Siparsky N, Ohe K, Mandell KA, DeUgarte DA, Kaji AH, Uribe L, Kao LS, Mueck KM, Farjah F, Self WH, Clark S, Drake FT, Fischkoff K, Minko E, Cuschieri J, Faine B, Skeete DA, Dhanani N, Liang MK, Krishnadasan A, Talan DA, Fannon E, Kessler LG, Comstock BA, Heagerty PJ, Monsell SE, Lawrence SO, Flum DR, Lavallee DC, Writing Group for the CODA Collaborative| | PubMed
  22. Analysis of Outcomes Associated With Outpatient Management of Nonoperatively Treated Patients With Appendicitis.
    Writing Group for the CODA Collaborative, Talan DA, Moran GJ, Krishnadasan A, Monsell SE, Faine BA, Uribe L, Kaji AH, DeUgarte DA, Self WH, Shapiro NI, Cuschieri J, Glaser J, Park PK, Price TP, Siparsky N, Sanchez SE, Machado-Aranda DA, Victory J, Ayoung-Chee P, Chiang W, Corsa J, Evans HL, Ferrigno L, Garcia L, Hatch Q, Horton MD, Johnson J, Jones A, Kao LS, Kelly A, Kim D, Kutcher ME, Liang MK, Maghami N, McGrane K, Minko E, Mohr C, Neufeld M, Patton JH, Rog C, Rushing A, Sabbatini AK, Salzberg M, Thompson CM, Tichter A, Wisler J, Bizzell B, Fannon E, Lawrence SO, Voldal EC, Lavallee DC, Comstock BA, Heagerty PJ, Davidson GH, Flum DR, Kessler LG| | PubMed
  23. Self-selection vs Randomized Assignment of Treatment for Appendicitis.
    Writing Group for the CODA Collaborative, Davidson GH, Monsell SE, Evans H, Voldal EC, Fannon E, Lawrence SO, Krishnadasan A, Talan DA, Bizzell B, Heagerty PJ, Comstock BA, Lavallee DC, Villegas C, Winchell R, Thompson CM, Self WH, Kao LS, Dodwad SJ, Sabbatini AK, Droullard D, Machado-Aranda D, Gibbons MM, Kaji AH, DeUgarte DA, Ferrigno L, Salzberg M, Mandell KA, Siparsky N, Price TP, Raman A, Corsa J, Wisler J, Ayoung-Chee P, Victory J, Jones A, Kutcher M, McGrane K, Holihan J, Liang MK, Cuschieri J, Johnson J, Fischkoff K, Drake FT, Sanchez SE, Odom SR, Kessler LG, Flum DR| | PubMed
  24. Postinjury platelet aggregation and venous thromboembolism.
    Matthay ZA, Hellmann ZJ, Nunez-Garcia B, Fields AT, Cuschieri J, Neal MD, Berger JS, Luttrell-Williams E, Knudson MM, Cohen MJ, Callcut RA, Kornblith LZ| | PubMed
  25. Developing a National Trauma Research Action Plan: Results from the acute resuscitation, initial patient evaluation, imaging, and management research gap Delphi survey.
    Costantini TW, Galante JM, Braverman MA, Phuong J, Price MA, Cuschieri J, Godat LN, Holcomb JB, Coimbra R, Bulger EM, NTRAP Acute Resuscitation Panel| | PubMed
  26. Nonoperative Management in Blunt Splenic Trauma: Can Shock Index Predict Failure?
    Senekjian L, Robinson BRH, Meagher AD, Gross JA, Maier RV, Bulger EM, Arbabi S, Cuschieri J| | PubMed
  27. Patient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis.
    Writing Group for the CODA Collaborative, Monsell SE, Voldal EC, Davidson GH, Fischkoff K, Coleman N, Bizzell B, Price T, Narayan M, Siparsky N, Thompson CM, Ayoung-Chee P, Odom SR, Sanchez S, Drake FT, Johnson J, Cuschieri J, Evans HL, Liang MK, McGrane K, Hatch Q, Victory J, Wisler J, Salzberg M, Ferrigno L, Kaji A, DeUgarte DA, Gibbons MM, Alam HB, Scott J, Kao LS, Self WH, Winchell RJ, Villegas CM, Talan DA, Kessler LG, Lavallee DC, Krishnadasan A, Lawrence SO, Comstock B, Fannon E, Flum DR, Heagerty PJ| | PubMed
  28. A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients.
    Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ| | PubMed
  29. Utility and Outcome of Angioembolization for High-Grade Renal Trauma Management in a Large Hospital-Based Trauma Registry.
    Hakam N, Amend GM, Nabavizadeh B, Allen IE, Shaw NM, Cuschieri J, Wilson MW, Stein DM, Breyer BN| | PubMed
  30. Respiratory events after intensive care unit discharge in trauma patients: Epidemiology, outcomes, and risk factors.
    Rosen JE, Bulger EM, Cuschieri J| | PubMed
  31. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.
    COVIDSurg Collaborative| | PubMed
  32. Antibiotics versus Appendectomy for Acute Appendicitis - Longer-Term Outcomes.
    CODA Collaborative, Davidson GH, Flum DR, Monsell SE, Kao LS, Voldal EC, Heagerty PJ, Fannon E, Lavallee DC, Bizzell B, Lawrence SO, Comstock BA, Krishnadasan A, Winchell RJ, Self WH, Thompson CM, Farjah F, Park PK, Alam HB, Saltzman D, Moran GJ, Kaji AH, DeUgarte DA, Salzberg M, Ferrigno L, Mandell KA, Price TP, Siparsky N, Glaser J, Ayoung-Chee P, Chiang W, Victory J, Chung B, Carter DW, Kutcher ME, Jones A, Holihan J, Liang MK, Faine BA, Cuschieri J, Evans HL, Johnson J, Patton JH, Coleman N, Fischkoff K, Drake FT, Sanchez SE, Parsons C, Odom SR, Kessler LG, Talan DA| | PubMed
  33. Chronic critical illness after hypothermia in trauma patients.
    Miranda D, Maine R, Cook M, Brakenridge S, Moldawer L, Arbabi S, O'Keefe G, Robinson B, Bulger EM, Maier R, Cuschieri J| | PubMed
  34. Multi-center validation of the Bowel Injury Predictive Score (BIPS) for the early identification of need to operate in blunt bowel and mesenteric injuries.
    Wandling M, Cuschieri J, Kozar R, O'Meara L, Celii A, Starr W, Burlew CC, Todd SR, de Leon A, McIntyre RC, Urban S, Biffl WL, Bayat D, Dunn J, Peck K, Rooney AS, Kornblith LZ, Callcut RA, Lollar DI, Ambroz E, Leichtle SW, Aboutanos MB, Schroeppel T, Hennessy EA, Russo R, McNutt M| | PubMed
  35. The Covid-19 Pandemic: Lessons Learned for Sustained Trauma Preparedness and Responses.
    Cuschieri J, Robinson B, Lynch J, Mitchell S, Arbabi S, Bryson C, Sayre M, Maier RV, Bulger E| | PubMed
  36. Aspirin versus anticoagulation for stroke prophylaxis in blunt cerebrovascular injury: a propensity-matched retrospective cohort study.
    Bonow RH, Witt CE, Mossa-Basha M, Cuschieri J, Arbabi S, Vavilala MS, Rivara FP, Chesnut RM| | PubMed
  37. PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients.
    O'Toole RV, Stein DM, Frey KP, O'Hara NN, Scharfstein DO, Slobogean GP, Taylor TJ, Haac BE, Carlini AR, Manson TT, Sudini K, Mullins CD, Wegener ST, Firoozabadi R, Haut ER, Bosse MJ, Seymour RB, Holden MB, Gitajn IL, Goldhaber SZ, Eastman AL, Jurkovich GJ, Vallier HA, Gary JL, Kleweno CP, Cuschieri J, Marvel D, Castillo RC, METRC| | PubMed
  38. Venous thromboembolism prophylaxis in the trauma intensive care unit: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document.
    Rappold JF, Sheppard FR, Carmichael Ii SP, Cuschieri J, Ley E, Rangel E, Seshadri AJ, Michetti CP| | PubMed
  39. Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
    Brakenridge SC, Wang Z, Cox M, Raymond S, Hawkins R, Darden D, Ghita G, Brumback B, Cuschieri J, Maier RV, Moore FA, Mohr AM, Efron PA, Moldawer LL| | PubMed
  40. Persistent metabolomic alterations characterize chronic critical illness after severe trauma.
    Horn DL, Bettcher LF, Navarro SL, Pascua V, Neto FC, Cuschieri J, Raftery D, O'Keefe GE| | PubMed
  41. Changes in error patterns in unanticipated trauma deaths during 20 years: In pursuit of zero preventable deaths.
    LaGrone LN, McIntyre L, Riggle A, Robinson BRH, Maier RV, Bulger E, Cuschieri J| | PubMed
  42. A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.
    CODA Collaborative, Flum DR, Davidson GH, Monsell SE, Shapiro NI, Odom SR, Sanchez SE, Drake FT, Fischkoff K, Johnson J, Patton JH, Evans H, Cuschieri J, Sabbatini AK, Faine BA, Skeete DA, Liang MK, Sohn V, McGrane K, Kutcher ME, Chung B, Carter DW, Ayoung-Chee P, Chiang W, Rushing A, Steinberg S, Foster CS, Schaetzel SM, Price TP, Mandell KA, Ferrigno L, Salzberg M, DeUgarte DA, Kaji AH, Moran GJ, Saltzman D, Alam HB, Park PK, Kao LS, Thompson CM, Self WH, Yu JT, Wiebusch A, Winchell RJ, Clark S, Krishnadasan A, Fannon E, Lavallee DC, Comstock BA, Bizzell B, Heagerty PJ, Kessler LG, Talan DA| | PubMed
  43. Society of Interventional Radiology Clinical Practice Guideline for Inferior Vena Cava Filters in the Treatment of Patients with Venous Thromboembolic Disease: Developed in collaboration with the American College of Cardiology, American College of Chest P
    Kaufman JA, Barnes GD, Chaer RA, Cuschieri J, Eberhardt RT, Johnson MS, Kuo WT, Murin S, Patel S, Rajasekhar A, Weinberg I, Gillespie DL| | PubMed
  44. Authors' reply: Understanding state-level Medicaid expansion in the context of nationwide data.
    Scott JW, Shrime MG, Stewart BT, Arbabi S, Bulger EM, Cuschieri J, Maier RV, Robinson BRH| | PubMed
  45. Splenic artery angioembolization for high-grade splenic injury: Are we wasting money?
    Senekjian L, Cuschieri J, Robinson BRH| | PubMed
  46. Predictors of mortality, limb loss, and discharge disposition at admission among patients with necrotizing skin and soft tissue infections.
    Horn DL, Shen J, Roberts E, Wang TN, Li KS, O'Keefe GE, Cuschieri J, Bulger EM, Robinson BRH| | PubMed
  47. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.
    COVIDSurg Collaborative| | PubMed
  48. Prospective Validation of a Transcriptomic Metric in Severe Trauma.
    Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL| | PubMed
  49. Proceedings from the Consensus Conference on Trauma Patient-Reported Outcome Measures.
    Sakran JV, Ezzeddine H, Schwab CW, Bonne S, Brasel KJ, Burd RS, Cuschieri J, Ficke J, Gaines BA, Giacino JT, Gibran NS, Haider A, Hall EC, Herrera-Escobar JP, Joseph B, Kao L, Kurowski BG, Livingston D, Mandell SP, Nehra D, Sarani B, Seamon M, Yonclas P, Zarzaur B, Stewart R, Bulger E, Nathens AB, Patient Reported Outcome Consortium| | PubMed
  50. Contemporary hemodynamic monitoring, fluid responsiveness, volume optimization, and endpoints of resuscitation: an AAST critical care committee clinical consensus.
    Martin ND, Codner P, Greene W, Brasel K, Michetti C, AAST Critical Care Committee| | PubMed
  51. Lifting the burden: State Medicaid expansion reduces financial risk for the injured.
    Scott JW, Shrime MG, Stewart BT, Arbabi S, Bulger EM, Cuschieri J, Maier RV, Robinson BRH| | PubMed
  52. Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.
    Stortz JA, Hawkins RB, Holden DC, Raymond SL, Wang Z, Brakenridge SC, Cuschieri J, Moore FA, Maier RV, Moldawer LL, Efron PA| | PubMed
  53. Ventilator-associated events, not ventilator-associated pneumonia, is associated with higher mortality in trauma patients.
    Meagher AD, Lind M, Senekjian L, Iwuchukwu C, Lynch JB, Cuschieri J, Robinson BRH| | PubMed
  54. Authors Response to Commentary on our Manuscript.
    Cook MR, Cuschieri J| | PubMed
  55. Trauma Surgeon and Palliative Care Physician Attitudes Regarding Goals-of-Care Delineation for Injured Geriatric Patients.
    Cunningham HB, Scielzo SA, Nakonezny PA, Bruns BR, Brasel KJ, Inaba K, Brakenridge SC, Kerby JD, Joseph BA, Mohler MJ, Cuschieri J, Paulk ME, Ekeh AP, Madni TD, Taveras LR, Imran JB, Wolf SE, Phelan HA| | PubMed
  56. Burn Surgeon and Palliative Care Physician Attitudes Regarding Goals of Care Delineation for Burned Geriatric Patients.
    Cunningham HB, Scielzo SA, Nakonezny PA, Bruns BR, Brasel KJ, Inaba K, Brakenridge SC, Kerby JD, Joseph BA, Mohler MJ, Cuschieri J, Paulk ME, Ekeh AP, Madni TD, Taveras LR, Imran JB, Wolf SE, Phelan HA| | PubMed
  57. Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures.
    O'Connell KM, Quistberg DA, Tessler R, Robinson BRH, Cuschieri J, Maier RV, Rivara FP, Vavilala MS, Bhalla PI, Arbabi S| | PubMed
  58. Unique Uses of Cooling Strategies.
    Lyden P, Paul J, Yokobori S, Cuschieri J| | PubMed
  59. Duration of Respiratory Failure After Trauma Is Not Associated With Increased Long-Term Mortality.
    Cook MR, O'Connell K, Qiu Q, Riggle AJ, Shoultz TH, Maine RG, Arbabi S, O'Keefe GE, Cuschieri J, Maier RV, Robinson BRH| | PubMed
  60. Effect of Standardized Handoff Curriculum on Improved Clinician Preparedness in the Intensive Care Unit: A Stepped-Wedge Cluster Randomized Clinical Trial.
    Parent B, LaGrone LN, Albirair MT, Serina PT, Keller JM, Cuschieri J, Addison EJ, Choe L, Delossantos GB, Gaskill CE, Moon SD, MacDonald JT, Stolzberg MJ, Van Eaton EG, Zech JM, Kritek PA| | PubMed
  61. Fellowship training in extracorporeal life support: Characterization and educational needs assessment.
    Cook MR, Badulak J, Çoruh B, Kiraly LN, Zonies D, Cuschieri J, Bulger EM| | PubMed
  62. Short-Course Antimicrobial Therapy Does Not Increase Treatment Failure Rate in Patients with Intra-Abdominal Infection Involving Fungal Organisms.
    Elwood NR, Guidry CA, Duane TM, Cuschieri J, Cook CH, O'Neill PJ, Askari R, Napolitano LM, Namias N, Dellinger EP, Watson CM, Banton KL, Blake DP, Hassinger TE, Sawyer RG| | PubMed
  63. A cohort study of blunt cerebrovascular injury screening in children: Are they just little adults?
    Cook MR, Witt CE, Bonow RH, Bulger EM, Linnau KF, Arbabi S, Robinson BRH, Cuschieri J| | PubMed
  64. The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
    Mira JC, Cuschieri J, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Loftus TJ, Stortz JA, Raymond SL, Lanz JD, Hennessy LV, Brumback B, Efron PA, Baker HV, Moore FA, Maier RV, Moldawer LL, Brakenridge SC| | PubMed
  65. Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections.
    Celestin AR, Odom SR, Angelidou K, Evans SR, Coimbra R, Guidry CA, Cuschieri J, Banton KL, O'Neill PJ, Askari R, Namias N, Duane TM, Claridge JA, Dellinger EP, Sawyer RA, Cook CH| | PubMed
  66. Does Isolation of Enterococcus Affect Outcomes in Intra-Abdominal Infections?
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  152. The evolution of the diagnostic work-up for stab wounds to the back and flank.
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  155. Necrotizing soft tissue infection.
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  156. An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.
    Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, Rosengart MR, Maier RV, Billiar TR, Peitzman AB, Moore EE, Inflammation the Host Response to Injury Investigators| | PubMed
  157. Inflammation and the host response to injury a large-scale collaborative project: patient-oriented research core standard operating procedure for clinical care X. Guidelines for venous thromboembolism prophylaxis in the trauma patient.
    Cuschieri J, Freeman B, O'Keefe G, Harbrecht BG, Bankey P, Johnson JL, Minei JP, Sperry J, West M, Nathens A, Moore EE, Maier RV, Inflammation and the Host Response to Injury Collaborative Research Program| | PubMed
  158. Negative appendectomy and imaging accuracy in the Washington State Surgical Care and Outcomes Assessment Program.
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  159. Survey of surgical infections currently known (SOSICK): a multicenter examination of antimicrobial use from the surgical infection society scientific studies committee.
    Namias N, Meizoso JP, Livingston DH, SOSICK Investigators Group| | PubMed
  160. Effect of immediate enteral feeding on trauma patients with an open abdomen: protection from nosocomial infections.
    Dissanaike S, Pham T, Shalhub S, Warner K, Hennessy L, Moore EE, Maier RV, O'Keefe GE, Cuschieri J| | PubMed
  161. Early supplemental parenteral nutrition is associated with increased infectious complications in critically ill trauma patients.
    Sena MJ, Utter GH, Cuschieri J, Maier RV, Tompkins RG, Harbrecht BG, Moore EE, O'Keefe GE| | PubMed
  162. Male gender is associated with excessive IL-6 expression following severe injury.
    Sperry JL, Friese RS, Frankel HL, West MA, Cuschieri J, Moore EE, Harbrecht BG, Peitzman AB, Billiar TR, Maier RV, Remick DG, Minei JP, Inflammation and the Host Response to Injury Investigators| | PubMed
  163. Emergency department ventilation effects outcome in severe traumatic brain injury.
    Warner KJ, Cuschieri J, Copass MK, Jurkovich GJ, Bulger EM| | PubMed
  164. Insulin regulates macrophage activation through activin A.
    Cuschieri J, Bulger E, Grinsell R, Garcia I, Maier RV| | PubMed
  165. Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeutic.
    Johns RE, El-Sayed ME, Bulmus V, Cuschieri J, Maier R, Hoffman AS, Stayton PS| | PubMed
  166. Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core-standard operating procedures for clinical care: VI. Blood glucose control in the critically ill trauma patient.
    Harbrecht BG, Minei JP, Shapiro MB, Nathens AB, Moore EE, West MA, Bankey PE, Cuschieri J, Johnson JL, Maier RV, Inflammation and the Host Response to Injury Scale Collaborative Research Project| | PubMed
  167. Oxidative stress, lipid rafts, and macrophage reprogramming.
    Cuschieri J, Maier RV| | PubMed
  168. The impact of prehospital ventilation on outcome after severe traumatic brain injury.
    Warner KJ, Cuschieri J, Copass MK, Jurkovich GJ, Bulger EM| | PubMed
  169. The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway.
    Schaeffer V, Cuschieri J, Garcia I, Knoll M, Billgren J, Jelacic S, Bulger E, Maier R| | PubMed
  170. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock.
    Bulger EM, Cuschieri J, Warner K, Maier RV| | PubMed
  171. The practice of venous thromboembolism prophylaxis in the major trauma patient.
    Nathens AB, McMurray MK, Cuschieri J, Durr EA, Moore EE, Bankey PE, Freeman B, Harbrecht BG, Johnson JL, Minei JP, McKinley BA, Moore FA, Shapiro MB, West MA, Tompkins RG, Maier RV| | PubMed
  172. Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.
    Cuschieri J, Bulger E, Billgrin J, Garcia I, Maier RV| | PubMed
  173. Vitamin E inhibits endotoxin-mediated transport of phosphatases to lipid rafts.
    Cuschieri J, Bulger E, Biligren J, Garcia I, Maier RV| | PubMed
  174. Surgical management of acute necrotizing lung infections.
    Reimel BA, Krishnadasen B, Cuschieri J, Klein MB, Gross J, Karmy-Jones R| | PubMed
  175. Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation.
    Cuschieri J, Billigren J, Maier RV| | PubMed
  176. Phosphatidylcholine-specific phospholipase C (PC-PLC) is required for LPS-mediated macrophage activation through CD14.
    Cuschieri J, Billgren J, Maier RV| | PubMed
  177. The modeling of the radiation and response green's function of a fluid-loaded cylindrical shell with an external compliant layer.
    Cuschieri JM| | PubMed
  178. Mitogen-activated protein kinase (MAPK).
    Cuschieri J, Maier RV| | PubMed
  179. Accidental self-inflicted nail gun injury to the heart
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  180. Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts.
    Cuschieri J, Bulger E, Garcia I, Maier RV| | PubMed
  181. Central venous-arterial carbon dioxide difference as an indicator of cardiac index.
    Cuschieri J, Rivers EP, Donnino MW, Katilius M, Jacobsen G, Nguyen HB, Pamukov N, Horst HM| | PubMed
  182. Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming.
    Cuschieri J, Bulger E, Garcia I, Jelacic S, Maier RV| | PubMed
  183. The role of repeat angiography in the management of pelvic fractures.
    Shapiro M, McDonald AA, Knight D, Johannigman JA, Cuschieri J| | PubMed
  184. PKC-zeta is essential for endotoxin-induced macrophage activation.
    Cuschieri J, Umanskiy K, Solomkin J| | PubMed
  185. Implications of lipid raft disintegration: enhanced anti-inflammatory macrophage phenotype.
    Cuschieri J| | PubMed
  186. Implications of proteasome inhibition: an enhanced macrophage phenotype.
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  187. Modulation of macrophage responsiveness to lipopolysaccharide by IRAK-1 manipulation.
    Cuschieri J, Bulmus V, Gourlay D, Garcia I, Hoffman A, Stayton P, Maier RV| | PubMed
  188. Modulation of endotoxin-induced endothelial function by calcium/calmodulin-dependent protein kinase.
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  189. NADPH oxidase activation in fibronectin adherent human neutrophils: A potential role for beta1 integrin ligation.
    Umanskiy K, Robinson C, Cave C, Williams MA, Lentsch AB, Cuschieri J, Solomkin JS| | PubMed
  190. Platelet-activating factor acetylhydrolase inhibits alveolar macrophage activation in vivo.
    Bulger EM, Gourlay D, Cuschieri J, Jelacic S, Staudenmeyer K, Garcia I, Maier RV| | PubMed
  191. Endotoxin-induced endothelial cell proinflammatory phenotypic differentiation requires stress fiber polymerization.
    Cuschleri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  192. Modulation of endotoxin-induced endothelial activity by microtubule depolymerization.
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  193. Stress-Induced Endothelial Cell Proinflammatory Phenotypic Differentiation Requires Stress Fiber Polymerization
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV.| | UCSF Research Profile
  194. Accidental self-inflicted nail gun injury to the heart
    Pritts TA, Knight D, Davis BR, Promebka D, Cuschieri J| | UCSF Research Profile
  195. Platelet-activating factor priming of inflammatory cell activity requires cellular adherence.
    Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV| | PubMed
  196. Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness.
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  197. Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin.
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV| | PubMed
  198. Role of bronchoscopy in massive hemoptysis.
    Karmy-Jones R, Cuschieri J, Vallières E| | PubMed
  199. Endotoxin Tolerance in Endothelial Cells is Reversed by Phosphatase Inhibition
    Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV.| | UCSF Research Profile
  200. Clearing the cervical spine in victims of blunt assault to the head and neck: what is necessary?
    Patton JH, Kralovich KA, Cuschieri J, Gasparri M| | PubMed
  201. Anterior mediastinal abscess after closed sternal fracture.
    Cuschieri J, Kralovich KA, Patton JH, Horst HM, Obeid FN, Karmy-Jones R| | PubMed