Biography
Chris E. Freise, M.D. received his medical degree from the University of Minnesota where he also did his internship and residency in General Surgery. He later completed a transplantation fellowship at UCSF.
He is a member of numerous professional organizations including The Transplantation Society, the International Pancreas and Islet Transplant Association, the Transplant Infectious Disease Society, the American Hepato-Pancreato-Billiary Association and the Society of University Surgeons. In addition, he recently served as the Medical Director for California Transplant Donor Network. He is also the Associate Counselor for UNOS Region 5, and a member of the UNOS Membership and Professional Standards Committee.
Dr. Freise has authored more than eighty (80) in peer-reviewed publications and five (5) book chapters. He is an accomplished researcher and clinical educator. Dr. Freise is also a frequent invited lecturer to national and international and conferences in the field.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California, San Francisco | Transplant Fellowship | School of Medicine | 1995 |
University of California, San Francisco | Post-Doc Fellow/Scholar | School of Medicine | 1991 |
University of Minnesota | M.D. | School of Medicine | 1986 |
Board Certifications
- American Board of Surgery, 1995
Clinical Expertise
Bile Duct Injuries
Bile Duct Strictures
Cholangiocarcinoma (Bile Duct Cancer)
Choledochal Cyst Disease
Dialysis Access
Expanded Criteria Donor Kidney Transplantation
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Intestinal Transplantation and Rehabilitation
Kidney and LIver Transplantation in HIV Patients
Kidney Auto-transplantation
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Laparoscopic Kidney and Liver Surgery
Liver Transplantation
Living Donor Kidney Transplantation
Living Donor Liver Transplantation
Pancreas Transplantation
Pediatric Kidney Transplantation
Pediatric Liver Transplantation
Polycystic Kidney Disease
Polycystic Liver Disease
Portal Hypertension
Surgical Shunts
Grants and Funding
- Living Donor Liver Transplant :Short & Long-Term Impact on Donors and Recipients | NIH | 2002-09-01 - 2015-08-31 | Role: Principal Investigator
Research Narrative
Dr. Friese's basic science research focuses on the delivery of immunosuppressive agents to organ allografts, ischemia reperfusion injury, and methods to improve organ function in deceased donors. His clinical research includes a multicenter trial investigating donor and recipient outcomes following living donor liver transplantation.
Research Interests
Delivery of Immunosuppressive Agents to Organ Allografts
Ischemia Reperfusion Injury
Improvement Organ Function in Deceased Donors
Publications
- Ureteral avulsion after ureteroscopy treated with renal auto-transplantation.| | PubMed
- Peritoneal Dialysis Catheter Complications after Insertion by Surgeons, Radiologists, or Nephrologists.| | PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed
- Motivations and outcomes of compatible living donor-recipient pairs in paired exchange.| | PubMed
- Retransplantation After Living Donor Liver Transplantation: Data from the Adult to Adult Living Donor Liver Transplantation Study.| | PubMed
- Biliary obstruction following ureteral revision of a transplanted kidney.| | PubMed
- Setting rules for the sandbox: A response to "Successfully sharing the sandbox: A perspective on combined DCD liver and heart donor procurement".| | PubMed
- Treatment of immunocompromised COVID-19 patients with convalescent plasma.| | PubMed
- Opioid use prior to liver transplant is associated with increased risk of death after transplant.| | PubMed
- Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients.| | PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | PubMed
- Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study.| | PubMed
- Inferior Long-Term Graft Survival of Suboptimal Kidneys After Living Donor Kidney Transplantation.| | PubMed
- Rapid Modification of Workflows and Fellow Staffing at a Single Transplant Center to Address the COVID-19 Crisis.| | PubMed
- Living Donor Liver Transplant for Alcoholic Liver Disease: Data from the Adult-to-adult Living Donor Liver Transplantation Study.| | PubMed
- Bi-organ paired exchange-Sentinel case of a liver-kidney swap.| | PubMed
- Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.| | PubMed
- Splenic Vein Thrombosis Following Pancreas Transplantation: Identification of Factors That Support Conservative Management.| | PubMed
- Collagen XIV and a related recombinant fragment protect human vascular smooth muscle cells from calcium-/phosphate-induced osteochondrocytic transdifferentiation.| | PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | PubMed
- Vascular complication rates in living donor liver transplantation: How low can we go?| | PubMed
- A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy.| | PubMed
- De novo thyroid cancer following solid organ transplantation-A 25-year experience at a high-volume institution with a review of the literature.| | PubMed
- Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2).| | PubMed
- Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.| | PubMed
- Impact of Graft Selection on Donor and Recipient Outcomes After Living Donor Liver Transplantation.| | PubMed
- Psychosocial Outcomes 3 to 10 Years After Donation in the Adult to Adult Living Donor Liver Transplantation Cohort Study.| | PubMed
- Complications and Their Resolution in Recipients of Deceased and Living Donor Liver Transplants: Findings From the A2ALL Cohort Study.| | PubMed
- Defining long-term outcomes with living donor liver transplantation in North America.| | PubMed
- Laparoscopic Nephrectomy with Autotransplantation: Safety, Efficacy and Long-Term Durability.| | PubMed
- Liver regeneration after living donor transplantation: adult-to-adult living donor liver transplantation cohort study.| | PubMed
- Long-term quality of life after liver donation in the adult to adult living donor liver transplantation cohort study (A2ALL).| | PubMed
- Restricting liver transplant recipients to younger donors does not increase the wait-list time or the dropout rate: the hepatitis C experience.| | PubMed
- Emesis following laparoscopic left donor nephrectomy.| | PubMed
- Ex vivo split-liver transplantation: the true right/left split.| | PubMed
- Outcomes of living and deceased donor liver transplant recipients with hepatocellular carcinoma: results of the A2ALL cohort.| | PubMed
- Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma.| | PubMed
- Complications of living donor hepatic lobectomy--a comprehensive report.| | PubMed
- Use of living donor liver transplantation varies with the availability of deceased donor liver transplantation.| | PubMed
- Outcomes with split liver transplantation in 106 recipients: the University of California, San Francisco, experience from 1993 to 2010.| | PubMed
- Liver transplantation for giant hepatic angiomyolipoma.| | PubMed
- Experience with laparoscopic donor nephrectomy among more than 1000 cases: low complication rates, despite more challenging cases.| | PubMed
- Ten-year retrospective analysis of incisional herniorrhaphy following renal transplantation.| | PubMed
- Fibrin plug.| | PubMed
- Outcomes of surgical repair of bile leaks and strictures after adult-to-adult living donor liver transplant.| | PubMed
- Comparison of biliary complications in adult living-donor liver transplants performed at two busy transplant centers.| | PubMed
- Inguinal herniation of a transplant ureter.| | PubMed
- Emergent orthotopic liver transplantation for hemorrhage from a giant cavernous hepatic hemangioma: case report and review.| | PubMed
- Left lobe adult-to-adult living donor liver transplantation: small grafts and hemiportocaval shunts in the prevention of small-for-size syndrome.| | PubMed
- Open incisional hernia repair at an academic tertiary care medical center.| | PubMed
- Prostate cancer screening and treatment in the transplant population: current status and recommendations.| | PubMed
- Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma.| | PubMed
- Recipient morbidity after living and deceased donor liver transplantation: findings from the A2ALL Retrospective Cohort Study.| | PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed
- Outcomes of living donor liver transplantation for acute liver failure: the adult-to-adult living donor liver transplantation cohort study.| | PubMed
- Donor morbidity after living donation for liver transplantation.| | PubMed
- Organ donation and utilization in the United States, 1997-2006.| | PubMed
- HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.| | PubMed
- Long-term outcomes and late complications of laparoscopic nephrectomy with renal autotransplantation.| | PubMed
- Catheter-directed therapy for DVT after pancreas transplantation.| | PubMed
- Laparoscopic nephrectomy, ex vivo partial nephrectomy followed by allograft renal transplantation.| | PubMed
- Improvement in survival associated with adult-to-adult living donor liver transplantation.| | PubMed
- Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation.| | PubMed
- Glutamine donor pretreatment in rat kidney transplants with severe preservation reperfusion injury.| | PubMed
- Predicting biliary complications in right lobe liver transplant recipients according to distance between donor's bile duct and corresponding hepatic artery.| | PubMed
- Effect of mycophenolate mofetil on rat kidney grafts with prolonged cold preservation.| | PubMed
- A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation.| | PubMed
- End stage polycystic kidney disease: indications and timing of native nephrectomy relative to kidney transplantation.| | PubMed
- More than 500 consecutive laparoscopic donor nephrectomies without conversion or repeated surgery.| | PubMed
- Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium.| | PubMed
- Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient.| | PubMed
- H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants.| | PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | PubMed
- Laparoscopic right donor nephrectomy: a large single-center experience.| | PubMed
- Increased rejection in living unrelated versus living related kidney transplants does not affect short-term function and survival.| | PubMed
- Laparoscopic nephrectomy, ex vivo excision and autotransplantation for complex renal tumors.| | PubMed
- Early graft function after living donor kidney transplantation predicts rejection but not outcomes.| | PubMed
- Laparoscopic-assisted upper pole ureterocalicostomy using renal inversion and autotransplantation.| | PubMed
- Experience with steroid-free maintenance immunosuppression in simultaneous pancreas-kidney transplantation.| | PubMed
- Polyomavirus-associated nephropathy in simultaneous kidney-pancreas transplant recipients: a single-center experience.| | PubMed
- Technique, indications and outcomes of pure laparoscopic right donor nephrectomy.| | PubMed
- Pure laparoscopic right donor nephrectomy: step-by-step approach.| | PubMed
- Influence of donor pretreatment with N-acetylcysteine on ischemia/reperfusion injury in rat kidney grafts.| | PubMed
- Laparoscopic donor nephrectomy for pediatric recipients: outcomes analysis.| | PubMed
- Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury.| | PubMed
- Excellent short-term results with steroid-free maintenance immunosuppression in low-risk simultaneous pancreas-kidney transplantation.| | PubMed
- Laparoscopic radical nephrectomy for suspected renal cell carcinoma in dialysis-dependent patients.| | PubMed
- Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study.| | PubMed
- Management of lymphoceles after renal transplantation: laparoscopic versus open drainage.| | PubMed
- Sclerosing peritonitis.| | PubMed
- Expanded experience with laparoscopic nephrectomy and autotransplantation for severe ureteral injury.| | PubMed
- Techniques to optimize vascular control during laparoscopic donor nephrectomy.| | PubMed
- Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.| | PubMed
- Successful long-term outcomes using pediatric en bloc kidneys for transplantation.| | PubMed
- Laparoscopic nephrectomy and autotransplantation for severe iatrogenic ureteral injuries.| | PubMed
- A calcineurin inhibitor-sparing regimen with sirolimus, mycophenolate mofetil, and anti-CD25 mAb provides effective immunosuppression in kidney transplant recipients with delayed or impaired graft function.| | PubMed
- Experience with the use of sirolimus in liver transplantation--use in patients for whom calcineurin inhibitors are contraindicated.| | PubMed
- Prolonged cold ischemia time obviates the benefits of 0 HLA mismatches in renal transplantation.| | PubMed
- The effect of age and prolonged cold ischemia times on the national allocation of cadaveric renal allografts.| | PubMed
- Flow cytometry crossmatching as a predictor of acute rejection in sensitized recipients of cadaveric renal transplants.| | PubMed
- Liver transplantation for autoimmune hepatitis: rejection and recurrence.| | PubMed
- Effect of systemic cyclosporine on tumor recurrence after liver transplantation in a model of hepatocellular carcinoma.| | PubMed
- Simultaneous pancreas-kidney transplantation: an overview of indications, complications, and outcomes.| | PubMed
- Hepatic artery pseudoaneurysm with hemobilia following angioplasty after liver transplantation.| | PubMed
- Risks associated with conversion of stable patients after liver transplantation to the microemulsion formulation of cyclosporine.| | PubMed
- Increased morbidity and mortality of simultaneous pancreas-renal transplantation in patients over 49 years of age.| | PubMed
- Liver transplantation improves survival of rats bearing hepatoma-3924A.| | PubMed
- Hepatotoxins and liver transplantation decrease pulmonary metastases in rats with hepatoma.| | PubMed
- Low postoperative wound infection rates are possible following simultaneous pancreas-kidney transplantation.| | PubMed
- Increased efficacy of CSA following rearterialization in the rat OLTX model.| | PubMed
- The increased efficacy and decreased nephrotoxicity of a cyclosporine liposome.| | PubMed
- Major histocompatibility complex class I deficiency prolongs islet allograft survival.| | PubMed
- Nonoperative management of biliary leaks after orthotopic liver transplantation.| | PubMed
- Maintenance immunosuppression with prednisone and RS-61443 alone following liver transplantation.| | PubMed
- Isolation of functional MHC class I-deficient islet cells.| | PubMed
- Orthotopic liver transplantation for end-stage alcoholic liver disease.| | PubMed
- Acute liver rejection: evaluation with cell-directed MR contrast agents in a rat transplantation model.| | PubMed
- A modified vascular "sleeve" anastomosis for rearterialization in orthotopic liver transplantation in rats.| | PubMed
- Similar clinical presentation of neurotoxicity following FK 506 and cyclosporine in a liver transplant recipient.| | PubMed
- Wound healing after anorectal surgery in human immunodeficiency virus-infected patients.| | PubMed
- Demonstration of local immunosuppression with methylprednisolone in the sponge matrix allograft model.| | PubMed
- Characterization of a cyclosporine-containing liposome.| | PubMed
- Comparison of three regimens for cytomegalovirus prophylaxis in 147 liver transplant recipients.| | PubMed
- MHC expression on human hepatocytes before and after isolation.| | PubMed